Article
Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.
Molecular omics - 25 Sept 2023
Gunji Daigo, Narumi Ryohei, Muraoka Satoshi, Isoyama Junko, Ikemoto Narumi, Ishida Mimiko, Tomonaga Takeshi, Sakai Yoshiharu, Obama Kazutaka, Adachi Jun
Abstract excerpt
Colorectal cancer (CRC), a common malignant tumour of the gastrointestinal tract, is a life-threatening cancer worldwide. Mutations in KRAS and BRAF, the major driver mutation subtypes in CRC, activate the RAS pathway, contribute to tumorigenesis in CRC and are being investigated as potential therapeutic targets. Despite recent advances in clinical trials targeting KRASG12C or RAS downstream signalling molecules...
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