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Article

Methylation of the serotonin transporter gene moderates the depressive subjective effect of cocaine.

Behavioural brain research - 10 Feb 2022

Longtain Riley B, Graham David P, Harding Mark J, De La Garza Ii Richard, Nielsen David A

Abstract excerpt

Genetic variation in the serotonin transporter (SLC6A4) has been shown to moderate the acute subjective effects of cocaine. Methylation of the SLC6A4 gene is associated with decreased transcription of the serotonin transporter, leading to increased serotonin in the synapse. In this study, methylation of the SLC6A4 gene was investigated in the moderation of the subjective effects of cocaine. Non-treatment-seeking...

Topics

Administration, Intravenous
Adult
Cocaine
DNA Methylation
Depression
Genotype
Humans
Male
Middle Aged
Serotonin Plasma Membrane Transport Proteins
Young Adult

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Identifiers

PMID: 34798166
DOI: 10.1016/j.bbr.2021.113675
PMCID: PMC8671356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34798166-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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