Association of Serotonin Transporter Gene AluJb Methylation with Major Depression, Amygdala Responsiveness, 5-HTTLPR/rs25531 Polymorphism, and Stress.

doi:10.1038/npp.2017.273

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Article

Association of Serotonin Transporter Gene AluJb Methylation with Major Depression, Amygdala Responsiveness, 5-HTTLPR/rs25531 Polymorphism, and Stress.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2018

Schneider Ilona, Kugel Harald, Redlich Ronny, Grotegerd Dominik, Bürger Christian, Bürkner Paul-Christian, Opel Nils, Dohm Katharina, Zaremba Dario, Meinert Susanne, Schröder Nina, Straßburg Anna Milena, Schwarte Kathrin, Schettler Christiane, Ambrée Oliver, Rust Stephan, Domschke Katharina, Arolt Volker, Heindel Walter, Baune Bernhard T, Zhang Weiqi, Dannlowski Udo, Hohoff Christa

Abstract excerpt

DNA methylation profiles of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression, drive antidepressant treatment response and modify brain functions. This study investigated whether methylation of an AluJb element in the SLC6A4 promotor was associated with major depr...

Topics

Adult
Amygdala
Brain Mapping
DNA Methylation
Depressive Disorder, Major
Emotions
Epigenesis, Genetic
Facial Recognition
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Magnetic Resonance Imaging

Male

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Serotonin Plasma Membrane Transport Proteins

Stress, Psychological

Source

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Identifiers

PMID: 29114103
DOI: 10.1038/npp.2017.273
PMCID: PMC5916353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-29114103-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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