Article
Association of Serotonin Transporter Gene AluJb Methylation with Major Depression, Amygdala Responsiveness, 5-HTTLPR/rs25531 Polymorphism, and Stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2018
Schneider Ilona, Kugel Harald, Redlich Ronny, Grotegerd Dominik, Bürger Christian, Bürkner Paul-Christian, Opel Nils, Dohm Katharina, Zaremba Dario, Meinert Susanne, Schröder Nina, Straßburg Anna Milena, Schwarte Kathrin, Schettler Christiane, Ambrée Oliver, Rust Stephan, Domschke Katharina, Arolt Volker, Heindel Walter, Baune Bernhard T, Zhang Weiqi, Dannlowski Udo, Hohoff Christa
Abstract excerpt
DNA methylation profiles of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression, drive antidepressant treatment response and modify brain functions. This study investigated whether methylation of an AluJb element in the SLC6A4 promotor was associated with major depressive disorder (MDD), amygdala reactivity to emotional faces, 5-HTTLPR/rs25531 polymorphism, and recent stress. MDD...
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