Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing.

doi:10.1038/mp.2012.193

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Article

Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing.

Molecular psychiatry - 1 Jan 2014

Lohoff F W, Hodge R, Narasimhan S, Nall A, Ferraro T N, Mickey B J, Heitzeg M M, Langenecker S A, Zubieta J-K, Bogdan R, Nikolova Y S, Drabant E, Hariri A R, Bevilacqua L, Goldman D, Doyle G A

Abstract excerpt

Emotional behavior is in part heritable and often disrupted in psychopathology. Identification of specific genetic variants that drive this heritability may provide important new insight into molecular and neurobiological mechanisms involved in emotionality. Our results demonstrate that the presynaptic vesicular monoamine transporter 1 (VMAT1) Thr136Ile (rs1390938) polymorphism is functional in vitro, with the...

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PMID: 23337945
DOI: 10.1038/mp.2012.193
PMCID: PMC4311877

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