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Article

Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes.

Psychiatric genetics - 1 Oct 2017

Patriquin Michelle A, Hamon Sara C, Harding Mark J, Nielsen Ellen M, Newton Thomas F, De La Garza Richard, Nielsen David A

Abstract excerpt

OBJECTIVE: This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine. METHODS: Non-treatment-seeking cocaine-dependent individuals (N=66) were intravenously administered saline and cocaine (40 mg) in a randomized order. Participants self-reported subjective effects of cocaine using a visual analog scale starting before administration...

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Source

Open in PubMed Open full text

Identifiers

PMID: 28590957
DOI: 10.1097/YPG.0000000000000178
PMCID: PMC5572746

Genes

TPH2
TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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