Article
Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology.
Drug and alcohol dependence - 1 Jul 2014
Moeller Scott J, Parvaz Muhammad A, Shumay Elena, Wu Salina, Beebe-Wang Nicasia, Konova Anna B, Misyrlis Michail, Alia-Klein Nelly, Goldstein Rita Z
Abstract excerpt
BACKGROUND: Gene polymorphisms that affect serotonin signaling modulate reactivity to salient stimuli and risk for emotional disturbances. Here, we hypothesized that these serotonin genes, which have been primarily explored in depressive disorders, could also have important implications for drug addiction, with the potential to reveal important insights into drug symptomatology, severity, and/or possible sequelae...
Topics
- Adult
- Biogenic Monoamines
- Cocaine-Related Disorders
- Depression
- Evoked Potentials
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Monoamine Oxidase
- Polymorphism, Genetic
- Serotonin