Article
Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2015
Havranek Michael M, Vonmoos Matthias, Müller Christian P, Büetiger Jessica R, Tasiudi Eve, Hulka Lea M, Preller Katrin H, Mössner Rainald, Grünblatt Edna, Seifritz Erich, Quednow Boris B
Abstract excerpt
Cocaine users consistently develop working memory (WM) impairments but the mediating molecular mechanisms are unknown so far. Recent evidence suggests that the serotonin (5-HT) system is altered by chronic cocaine use, while also being involved in WM processing. Thus, we investigated the effects of genetic variations impacting 5-HT activity and of peripheral 5-HT transporter (5-HTT) mRNA expression on WM...
Topics
- Adult
- Cocaine-Related Disorders
- DNA Repeat Expansion
- Executive Function
- Female
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Humans
- Introns