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Article

Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2015

Havranek Michael M, Vonmoos Matthias, Müller Christian P, Büetiger Jessica R, Tasiudi Eve, Hulka Lea M, Preller Katrin H, Mössner Rainald, Grünblatt Edna, Seifritz Erich, Quednow Boris B

Abstract excerpt

Cocaine users consistently develop working memory (WM) impairments but the mediating molecular mechanisms are unknown so far. Recent evidence suggests that the serotonin (5-HT) system is altered by chronic cocaine use, while also being involved in WM processing. Thus, we investigated the effects of genetic variations impacting 5-HT activity and of peripheral 5-HT transporter (5-HTT) mRNA expression on WM...

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Identifiers

PMID: 26013962
DOI: 10.1038/npp.2015.146
PMCID: PMC4864628

Genes

HTT
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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