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Article

Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders.

Pharmacogenetics and genomics - 1 Jun 2015

Brewer Alex J, Nielsen David A, Spellicy Catherine J, Hamon Sara C, Gingrich Justin, Thompson-Lake Daisy G Y, Nielsen Ellen M, Mahoney James J, Kosten Thomas R, Newton Thomas F, De La Garza Richard

Abstract excerpt

OBJECTIVE: The aim of this study was to identify gene variants of DAT1 (SLC6A3) that modulate subjective responses to acute cocaine exposure. METHODS: Non-treatment-seeking volunteers (n=66) with cocaine use disorders received a single bolus infusion of saline and cocaine (40 mg, intravenous) in a randomized order. Subjective effects were assessed with visual analog scales administered before (-15 min) and up to...

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Identifiers

PMID: 25850966
DOI: 10.1097/FPC.0000000000000137
PMCID: PMC4414865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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