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Article

Genetic fusions favor tumorigenesis through degron loss in oncogenes.

Nature communications - 18 Nov 2021

Liu Jing, Tokheim Collin, Lee Jonathan D, Gan Wenjian, North Brian J, Liu X Shirley, Pandolfi Pier Paolo, Wei Wenyi

Abstract excerpt

Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in tumorigenesis and progression. Our study proposes a model whereby oncogenic gene fusions frequently alter the protein stability of the resulting fusion products, via exchanging protein degradation signal (degron) between gene sequences. Computational analyses of The Cancer Genome...

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Identifiers

PMID: 34795215
DOI: 10.1038/s41467-021-26871-y
PMCID: PMC8602260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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