Article
Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome.
Genome research - 1 May 2010
Quinlan Aaron R, Clark Royden A, Sokolova Svetlana, Leibowitz Mitchell L, Zhang Yujun, Hurles Matthew E, Mell Joshua C, Hall Ira M
Abstract excerpt
Structural variation (SV) is a rich source of genetic diversity in mammals, but due to the challenges associated with mapping SV in complex genomes, basic questions regarding their genomic distribution and mechanistic origins remain unanswered. We have developed an algorithm (HYDRA) to localize SV breakpoints by paired-end mapping, and a general approach for the genome-wide assembly and interpretation of...
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