Article
Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome.
Cell reports - 16 Nov 2021
Lin Raozhou, Learman Lisa N, Bangash M Ali, Melnikova Tatiana, Leyder Erica, Reddy Sai C, Naidoo Nirinjini, Park Joo Min, Savonenko Alena, Worley Paul F
Abstract excerpt
Mutations of SHANK3 cause Phelan-McDermid syndrome (PMS), and these individuals can exhibit sensitivity to stress, resulting in behavioral deterioration. Here, we examine the interaction of stress with genotype using a mouse model with face validity to PMS. In Shank3ΔC/+ mice, swim stress produces an altered transcriptomic response in pyramidal neurons that impacts genes and pathways involved in synaptic...
Topics
- Animals
- Chromosome Deletion
- Chromosome Disorders
- Chromosomes, Human, Pair 22
- Disease Models, Animal
- Gene Expression
- Gene Expression Regulation
- Homer Scaffolding Proteins
- Male
- Mice