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Article

The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

Nature structural & molecular biology - 1 Nov 2008

Xue Mingshan, Ma Cong, Craig Timothy K, Rosenmund Christian, Rizo Josep

Abstract excerpt

Synaptotagmin-1 functions as a Ca2+ sensor in neurotransmitter release and was proposed to act on both the synaptic vesicle and plasma membranes through interactions involving the Ca2+ binding top loops of its C(2) domains and the Ca2+-independent bottom face of the C(2)B domain. However, the functional importance of the C(2)B domain bottom face is unclear. We now show that mutating two conserved arginine...

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Identifiers

PMID: 18953334
DOI: 10.1038/nsmb.1508
PMCID: PMC2587052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.PMID 18953334Read ↗

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synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo.Semantic proximity Read ↗

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