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Article

Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity.

Neuron - 19 Apr 2007

Wierda Keimpe D B, Toonen Ruud F G, de Wit Heidi, Brussaard Arjen B, Verhage Matthijs

Abstract excerpt

Diacylglycerol (DAG) is a prominent endogenous modulator of synaptic transmission. Recent studies proposed two apparently incompatible pathways, via protein kinase C (PKC) and via Munc13. Here we show how these two pathways converge. First, we confirm that DAG analogs indeed continue to potentiate transmission after PKC inhibition (the Munc13 pathway), but only in neurons that previously experienced DAG analogs,...

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Identifiers

PMID: 17442248
DOI: 10.1016/j.neuron.2007.04.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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