Article
Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.
The Biochemical journal - 1 Mar 2016
Chicka Michael C, Ren Qiansheng, Richards David, Hellman Lance M, Zhang Jinchao, Fried Michael G, Whiteheart Sidney W
Abstract excerpt
The Munc13 family of exocytosis regulators has multiple Ca(2+)-binding, C2 domains. Here, we probed the mechanism by which Munc13-4 regulates in vitro membrane fusion and platelet exocytosis. We show that Munc13-4 enhances in vitro soluble NSF attachment protein receptor (SNARE)-dependent, proteoliposome fusion in a Ca(2+)- and phosphatidylserine (PS)-dependent manner that was independent of SNARE concentrations....
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