Article
Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.
Molecular and cellular biology - 1 Nov 2012
Lipstein Noa, Schaks Sabine, Dimova Kalina, Kalkhof Stefan, Ihling Christian, Kölbel Knut, Ashery Uri, Rhee JeongSeop, Brose Nils, Sinz Andrea, Jahn Olaf
Abstract excerpt
Munc13s are presynaptic proteins that mediate synaptic vesicle priming and thereby control the size of the readily releasable pool of vesicles. During high synaptic activity, Munc13-1 and its closely related homolog, ubMunc13-2, bind Ca(2+)/calmodulin, resulting in enhanced priming activity and in changes of short-term synaptic plasticity characteristics. Here, we studied whether bMunc13-2 and Munc13-3, two...
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