Article
Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample.
Journal of affective disorders - 20 Mar 2013
Peyrot Wouter J, Middeldorp Christel M, Jansen Rick, Smit Johannes H, de Geus Eco J C, Hottenga Jouke-Jan, Willemsen Gonneke, Vink Jacqueline M, Virding Susanne, Barragan Isabel, Ingelman-Sundberg Magnus, Sim Sarah C, Boomsma Dorret I, Penninx Brenda W J H
Abstract excerpt
BACKGROUND: There is ongoing interest in the possible interaction of the serotonin-transporter-linked polymorphic region (5-HTTLPR) with environmental factors in determining Major Depressive Disorder (MDD). The current study contributes to this research area by comprehensively examining the interaction-effects and direct-effects of 5-HTTLPR and five environmental factors on MDD prevalence and course in a...
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