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Article

Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers.

Development and psychopathology - 1 Dec 2017

Parade Stephanie H, Novick Andrew M, Parent Justin, Seifer Ronald, Klaver Samantha J, Marsit Carmen J, Gobin Asi Polly, Yang Bao-Zhu, Tyrka Audrey R

Abstract excerpt

Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within...

Topics

Child Abuse
Child, Preschool
DNA Methylation
Depressive Disorder, Major
Female
Gene-Environment Interaction
Genotype
Humans
Male
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Serotonin, 5-HT2A

Signal Transduction

Stress Disorders, Post-Traumatic

Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 29162169
DOI: 10.1017/S0954579417001274
PMCID: PMC5720374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29162169-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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