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Article

Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.

Journal of psychopharmacology (Oxford, England) - 1 Mar 2012

Xu Zhi, Zhang Zhijun, Shi Yanyan, Pu Mengjia, Yuan Yonggui, Zhang Xiangrong, Li Lingjiang, Reynolds Gavin P

Abstract excerpt

Variation in genes implicated in serotonin neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of polymorphisms in serotonergic genes determine this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10...

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Source

Identifiers

PMID: 21937687
DOI: 10.1177/0269881111414452

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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