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Article

TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

The international journal of neuropsychopharmacology - 1 Nov 2016

Xu Zhi, Reynolds Gavin P, Yuan Yonggui, Shi Yanyan, Pu Mengjia, Zhang Zhijun

Abstract excerpt

BACKGROUND: Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of single nucleotide polymorphisms in monoaminergic genes influence this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. An initial study of monoaminergic coding region...

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Source

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Identifiers

PMID: 27521242
DOI: 10.1093/ijnp/pyw070
PMCID: PMC5137282

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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