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Article

Differential Effects of Human P301L Tau Expression in Young versus Aged Mice.

International journal of molecular sciences - 28 Oct 2021

Hunsberger Holly C, Setti Sharay E, Rudy Carolyn C, Weitzner Daniel S, Pfitzer Jeremiah C, McDonald Kelli L, Hong Hao, Bhattacharya Subhrajit, Suppiramaniam Vishnu, Reed Miranda N

Abstract excerpt

The greatest risk factor for developing Alzheimer's disease (AD) is increasing age. Understanding the changes that occur in aging that make an aged brain more susceptible to developing AD could result in novel therapeutic targets. In order to better understand these changes, the current study utilized mice harboring a regulatable mutant P301L human tau transgene (rTg(TauP301L)4510), in which P301L tau expression...

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Identifiers

PMID: 34769068
DOI: 10.3390/ijms222111637
PMCID: PMC8583766

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