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Article

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy.

Alzheimer's research & therapy - 20 Sept 2017

Blackmore Thomas, Meftah Soraya, Murray Tracey Karen, Craig Peter James, Blockeel Anthony, Phillips Keith, Eastwood Brian, O'Neill Michael J, Marston Hugh, Ahmed Zeshan, Gilmour Gary, Gastambide Francois

Abstract excerpt

BACKGROUND: The choice and appropriate use of animal models in drug discovery for Alzheimer's disease (AD) is pivotal to successful clinical translation of novel therapeutics, yet true alignment of research is challenging. Current models do not fully recapitulate the human disease, and even exhibit various degrees of regional pathological burden and diverse functional alterations. Given this, relevant...

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Source

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Identifiers

PMID: 28931441
DOI: 10.1186/s13195-017-0306-2
PMCID: PMC5607580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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