Article
A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore.
eLife - 30 Oct 2020
Yeung Priscilla S-W, Ing Christopher E, Yamashita Megumi, Pomès Régis, Prakriya Murali
Abstract excerpt
Sulfur-aromatic interactions occur in the majority of protein structures, yet little is known about their functional roles in ion channels. Here, we describe a novel molecular motif, the M101 gate latch, which is essential for gating of human Orai1 channels via its sulfur-aromatic interactions with the F99 hydrophobic gate. Molecular dynamics simulations of different Orai variants reveal that the gate latch is...
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