Article

Sohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway

2023-03-22

Abstract excerpt

<title>Abstract</title> <p>Disturbance in the redox balance of alveolar epithelial cells (AECs) was considered as a causal factor for pulmonary fibrosis. The regulatory mechanisms of redox hemostasis in the development of pulmonary fibrosis remain largely unknown. Using a type II AEC-specific Sohlh2 conditional knock-in (CKI) mouse model, we found that Sohlh2, a basic HLH transcription factor, accelerated age-rel...

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Literature Corpus work: 4eb8f902-e662-5b03-99d2-bc7e92f04366
DOI: 10.21203/rs.3.rs-2602401/v1

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