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Article

Comparative Performance of Genomic Methods for the Detection of Pyrazinamide Resistance and Heteroresistance in Mycobacterium tuberculosis.

Journal of clinical microbiology - 19 Jan 2022

Whitfield Michael G, Engelthaler David M, Allender Christopher, Folkerts Megan, Heupink Tim H, Limberis Jason, Warren Robin M, Van Rie Annelies, Metcalfe John Z

Abstract excerpt

Pyrazinamide is an important component of both drug-susceptible and drug-resistant tuberculosis treatment regimens. Although approximately 50% of rifampin-resistant isolates are also resistant to pyrazinamide, pyrazinamide susceptibility testing is not routinely performed due to the challenging nature of the assay. We investigated the diagnostic accuracy of genotypic and phenotypic methods and explored the...

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Identifiers

PMID: 34757831
DOI: 10.1128/JCM.01907-21
PMCID: PMC8769725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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