Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That?

Journal of clinical microbiology - 1 Jun 2017

Werngren Jim, Alm Erik, Mansjö Mikael

Abstract excerpt

Pyrazinamide (PZA) is a key component for the effective treatment of drug-susceptible and PZA-susceptible multidrug-resistant (MDRPZA-S) tuberculosis (TB). pncA gene mutations are usually detected in a clear majority (>90%) of PZA-resistant strains but obviously not in all. Rapid and reliable PZA drug susceptibility testing (DST) is critical whenever PZA is to be used in a treatment regimen, not least for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Antitubercular Agents
Share to Coinfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium avium

Share to Mycobacterium tuberculosis

Share to Pyrazinamide

Share to Tuberculosis

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 28404681
DOI: 10.1128/JCM.02532-16
PMCID: PMC5442549

Genes

DST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That?PMID 28404681Read ↗

Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis clinical isolates in Hangzhou, China.Semantic proximity Read ↗

pncA Large Deletion is the Characteristic of Pyrazinamide-Resistant Mycobacterium tuberculosis belonging to the East Asian LineageSemantic proximity Read ↗

Pyrazinamide Resistance and pncA Mutation Profiles in Multidrug Resistant Mycobacterium TuberculosisSemantic proximity Read ↗

Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis.Semantic proximity Read ↗

A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.Semantic proximity Read ↗

Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study.Semantic proximity Read ↗

The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China.Semantic proximity Read ↗

Improved Detection by Next-Generation Sequencing of Pyrazinamide Resistance in Mycobacterium tuberculosis IsolatesSemantic proximity Read ↗

Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China.Semantic proximity Read ↗

Multicenter Study of the Emergence and Genetic Characteristics of Pyrazinamide-Resistant Tuberculosis in China.Semantic proximity Read ↗

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

High prevalence of phenotypic pyrazinamide resistance and its association with pncA gene mutations in Mycobacterium tuberculosis isolates from Uganda.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.