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Article

Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 18 May 2021

Modlin Samuel J, Marbach Tyler, Werngren Jim, Mansjö Mikael, Hoffner Sven E, Valafar Faramarz

Abstract excerpt

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to isoniazid and rifampin (i.e., multidrug resistance [MDR]) and is conferred by loss-of-function pncA mutations that inhibit conversion to its active form, pyrazinoic acid (POA). PZA-R departing from this canonical scenario is poorly...

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Identifiers

PMID: 33722890
DOI: 10.1128/AAC.01916-20
PMCID: PMC8315952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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