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Article

Is sequencing better than phenotypic tests for the detection of pyrazinamide resistance?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jun 2018

Bouzouita I, Cabibbe A M, Trovato A, Draoui H, Ghariani A, Midouni B, Essalah L, Mehiri E, Cirillo D M, Slim-Saidi L

Abstract excerpt

SETTING: Phenotypic tests used to detect pyrazinamide (PZA) resistance are slow and have a high rate of false resistance. OBJECTIVE: To evaluate the accuracy of pncA sequencing for the detection of PZA resistance in Mycobacterium tuberculosis strains isolated in Tunisia. DESIGN: A total of 82 isolates, 41 resistant and 41 susceptible to PZA on BACTEC™ MGIT™ 960, were sequenced for pncA. Whole genome sequencing...

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Identifiers

PMID: 29862951
DOI: 10.5588/ijtld.17.0715

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