Article
pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.
Emerging infectious diseases - 1 Mar 2017
Allana Salim, Shashkina Elena, Mathema Barun, Bablishvili Nino, Tukvadze Nestani, Shah N Sarita, Kempker Russell R, Blumberg Henry M, Moodley Pravi, Mlisana Koleka, Brust James C M, Gandhi Neel R
Abstract excerpt
Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.
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