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pncA Large Deletion is the Characteristic of Pyrazinamide-Resistant Mycobacterium tuberculosis belonging to the East Asian Lineage

1 Jan 2023

Abstract excerpt

Background: Pyrazinamide (PZA) is often used as an add-on agent in the treatment of multidrug-resistant tuberculosis, regardless of phenotypic drug susceptibility testing (pDST) results.However, evaluating the effectiveness of PZA is challenging because of its low pH activity, which can result in unreliable pDST results.This study aimed to investigate the genomic characteristics associated with PZA resistance...

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PMID: 37407242
DOI: 10.3947/ic.2023.0037

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