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Article

Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study.

mBio - 21 Oct 2014

Miotto Paolo, Cabibbe Andrea M, Feuerriegel Silke, Casali Nicola, Drobniewski Francis, Rodionova Yulia, Bakonyte Daiva, Stakenas Petras, Pimkina Edita, Augustynowicz-Kopeć Ewa, Degano Massimo, Ambrosi Alessandro, Hoffner Sven, Mansjö Mikael, Werngren Jim, Rüsch-Gerdes Sabine, Niemann Stefan, Cirillo Daniela M

Abstract excerpt

Pyrazinamide (PZA) is a prodrug that is converted to pyrazinoic acid by the enzyme pyrazinamidase, encoded by the pncA gene in Mycobacterium tuberculosis. Molecular identification of mutations in pncA offers the potential for rapid detection of pyrazinamide resistance (PZA(r)). However, the genetic variants are highly variable and scattered over the full length of pncA, complicating the development of a molecular...

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Identifiers

PMID: 25336456
DOI: 10.1128/mBio.01819-14
PMCID: PMC4212837

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