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Protective antigenic sites identified in respiratory syncytial virus fusion protein reveals importance of p27 domain

8 Nov 2021

Abstract excerpt

Respiratory syncytial virus (RSV) vaccines primarily focused on surface fusion (F) protein are under development. Therefore, to identify RSV-F protective epitopes, we evaluated 14 antigenic sites recognized following primary human RSV infection. BALB/c mice were vaccinated with F peptides, F proteins, or RSV-A2, followed by rA2-Line19F challenge. F peptides generated binding antibodies with minimal in vitro...

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PMID: 34750984
DOI: 10.15252/emmm.202013847

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