Article
Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.
Viruses - 14 Aug 2018
Leemans Annelies, Boeren Marlies, Van der Gucht Winke, Pintelon Isabel, Roose Kenny, Schepens Bert, Saelens Xavier, Bailey Dalan, Martinet Wim, Caljon Guy, Maes Louis, Cos Paul, Delputte Peter
Abstract excerpt
Prevention of severe lower respiratory tract infections in infants caused by the human respiratory syncytial virus (hRSV) remains a major public health priority. Currently, the major focus of vaccine development relies on the RSV fusion (F) protein since it is the main target protein for neutralizing antibodies induced by natural infection. The protein conserves 5 N-glycosylation sites, two of which are located...
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