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Article

Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B.

PloS one - 1 Jan 2017

Hause Anne M, Henke David M, Avadhanula Vasanthi, Shaw Chad A, Tapia Lorena I, Piedra Pedro A

Abstract excerpt

BACKGROUND: The fusion (F) protein of RSV is the major vaccine target. This protein undergoes a conformational change from pre-fusion to post-fusion. Both conformations share antigenic sites II and IV. Pre-fusion F has unique antigenic sites p27, ø, α2α3β3β4, and MPE8; whereas, post-fusion F has unique antigenic site I. Our objective was to determine the antigenic variability for RSV/A and RSV/B isolates from...

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Identifiers

PMID: 28414749
DOI: 10.1371/journal.pone.0175792
PMCID: PMC5393888

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