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Article

Postreplicative formation of cohesion is required for repair and induced by a single DNA break.

Science (New York, N.Y.) - 13 Jul 2007

Ström Lena, Karlsson Charlotte, Lindroos Hanna Betts, Wedahl Sara, Katou Yuki, Shirahige Katsuhiko, Sjögren Camilla

Abstract excerpt

Sister-chromatid cohesion, established during replication by the protein complex cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally, cohesion formation is strictly limited to the S phase of the cell cycle, but DSBs can trigger cohesion also after DNA replication has been completed. The function of this damage-induced cohesion remains unknown. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17626884
DOI: 10.1126/science.1140649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Postreplicative formation of cohesion is required for repair and induced by a single DNA break.PMID 17626884Read ↗

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