Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Determination of metabolic phenotype and potential biomarkers in the liver of heroin addicted mice with hepatotoxicity.

Life sciences - 15 Dec 2021

Li Liang, Li Jieyan, Cao Haijie, Wang Qiuhong, Zhou Zhengzheng, Zhao Hu, Kuang Haixue

Abstract excerpt

BACKGROUND: Heroin is a semi-synthetic opioid that is commonly abused drugs in the world. It can cause hepatic injury and lead to multiple organs dysfunction to its addicts. Only a few reports exist on the metabolic changes and mechanisms in the liver of heroin-addicted mice with hepatic injury. METHODS: Twelve adult male Kunming mice (30-40 g) were divided into two groups randomly. The mice in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Outbred Strains
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Heroin Dependence

Share to Metabolomics

Share to Phenotype

Source

Identifiers

PMID: 34743944
DOI: 10.1016/j.lfs.2021.120103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determination of metabolic phenotype and potential biomarkers in the liver of heroin addicted mice with hepatotoxicity.PMID 34743944Read ↗

Metabolic phenotype of rats exposed to heroin and potential markers of heroin abuse.Semantic proximity Read ↗

Could chronic opioid use be an additional risk of hepatic damage in patients with previous liver diseases, and what is the role of microbiome?Semantic proximity Read ↗

High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry.Semantic proximity Read ↗

Research on the Species Difference of the Hepatotoxicity of Medicine Based on TranscriptomeSemantic proximity Read ↗

Elevation of Gut-Derived p-Cresol During Spaceflight and its Effect on Drug Metabolism and Performance in AstronautsSemantic proximity Read ↗

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity.Semantic proximity Read ↗

Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAsSemantic proximity Read ↗

Metabolic phenotyping applied to pre-clinical drug induced liver injury and acute liver failureSemantic proximity Read ↗

Ingenuity pathways analysis of urine metabonomics phenotypes toxicity of gentamicin in multiple organs.Semantic proximity Read ↗

A UPLC-MS based exploration of the xenobiotic and endogenous metabolic phenotypes of pre-clinical models of hepatotoxicitySemantic proximity Read ↗

Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.Semantic proximity Read ↗

1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.