Article

A UPLC-MS based exploration of the xenobiotic and endogenous metabolic phenotypes of pre-clinical models of hepatotoxicity

2017-01-01

Abstract excerpt

To reduce late stage attrition during drug development, and improve the diagnosis of drug induced liver injury (DILI), a greater mechanistic understanding of DILI and improved predictive biomarkers are required. In this thesis, the xenobiotic and endogenous metabolic phenotypes of model hepatotoxins are studied in the rat using an ultra-performance liquid chromatography- mass spectrometry (UPLC-MS) based metabonom...

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Literature Corpus work: 8165a55f-2241-5176-b25a-4736c707b44a
DOI: 10.25560/68529

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