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Article

Metabolic phenotype of rats exposed to heroin and potential markers of heroin abuse.

Drug and alcohol dependence - 1 Jan 2013

Zheng Tian, Liu Linsheng, Aa Jiye, Wang Guangji, Cao Bei, Li Mengjie, Shi Jian, Wang Xinwen, Zhao Chunyan, Gu Rongrong, Zhou Jun, Xiao Wenjing, Yu Xiaoyi, Sun Runbing, Zhou Yahong, Zuo Yuexian, Zhu Xuanxuan

Abstract excerpt

BACKGROUND: Metabolomics allows the high-throughput analysis of low molecular mass compounds in biofluids, which can reflect the metabolic response of the body to heroin exposure and potentially reveal biomarkers of heroin abuse. METHODS: Heroin was administered to Sprague-Dawley rats in increasing doses from 3 to 16.5 mg kg(-1)d(-1) (i.p.) for 10 days, then withdrawn and re-administered for 4 days. The analytes...

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Identifiers

PMID: 22840430
DOI: 10.1016/j.drugalcdep.2012.06.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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