High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry.

doi:10.1039/c6mb00742b

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Article

High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry.

Molecular bioSystems - 20 Dec 2016

Zhang Tianlei, Zhang Aihua, Qiu Shi, Sun Hui, Han Ying, Guan Yu, Wang Xijun

Abstract excerpt

Alcohol-induced liver injury (ALD) shows obvious metabolic disorders, categorized by a wide range of metabolite abnormalities. High-throughput metabolomics technology appears to be an appropriate solution. In this study, a urine metabolic profile was assessed using a UPLC-Q-TOF/HDMS (liquid chromatography coupled to high resolution mass spectrometry) approach to investigate the underlying molecular mechanisms of...

Topics

Animals
Biomarkers
Biopsy
Chemical and Drug Induced Liver Injury
Chromatography, Liquid
Cluster Analysis
Disease Models, Animal
Ethanol
Immunohistochemistry
Iridoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mass Spectrometry

Metabolic Networks and Pathways

Metabolome

Metabolomics

Mice

Phenotype

Source

Open in PubMed

Identifiers

PMID: 27896352
DOI: 10.1039/c6mb00742b

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