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Article

Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Journal of hepatology - 1 Apr 2011

Begriche Karima, Massart Julie, Robin Marie-Anne, Borgne-Sanchez Annie, Fromenty Bernard

Abstract excerpt

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450. Depending of their nature and their severity, the mitochondrial alterations are able to...

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Source

Identifiers

PMID: 21145849
DOI: 10.1016/j.jhep.2010.11.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21145849-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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