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Article

Fragile axons forge the path to gene discovery: a MAP kinase pathway regulates axon regeneration.

Science signaling - 5 May 2009

O'Brien Georgeann S, Sagasti Alvaro

Abstract excerpt

The nematode Caenorhabditis elegans is emerging as a promising model for studying the molecular control of axon regeneration. A forward genetic screen identified the DLK-1 (dual leucine zipper-bearing kinase 1) MAP (mitogen-activated protein) kinase pathway as a positive regulator of growth cone formation during axon regeneration. Although DLK-1 pathway mutant animals display a dramatic defect in regeneration,...

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Source

Identifiers

PMID: 19417215
DOI: 10.1126/scisignal.269pe30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fragile axons forge the path to gene discovery: a MAP kinase pathway regulates axon regeneration.PMID 19417215Read ↗

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