Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Heterochronic Gene lin-14 Controls Axonal Degeneration in C. elegans Neurons.

Cell reports - 19 Sept 2017

Ritchie Fiona K, Knable Rhianna, Chaplin Justin, Gursanscky Rhiannon, Gallegos Maria, Neumann Brent, Hilliard Massimo A

Abstract excerpt

The disproportionate length of an axon makes its structural and functional maintenance a major task for a neuron. The heterochronic gene lin-14 has previously been implicated in regulating the timing of key developmental events in the nematode C. elegans. Here, we report that LIN-14 is critical for maintaining neuronal integrity. Animals lacking lin-14 display axonal degeneration and guidance errors in both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Axons
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Helminth

Share to Microtubules

Share to Nerve Degeneration

Share to Nuclear Proteins

Share to Synapses

Source

Identifiers

PMID: 28930688
DOI: 10.1016/j.celrep.2017.08.083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Heterochronic Gene lin-14 Controls Axonal Degeneration in C. elegans Neurons.PMID 28930688Read ↗

LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.Semantic proximity Read ↗

Genes necessary for directed axonal elongation or fasciculation in C. elegans.Semantic proximity Read ↗

Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cord.Semantic proximity Read ↗

A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.Semantic proximity Read ↗

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.Semantic proximity Read ↗

Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans.Semantic proximity Read ↗

Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.Semantic proximity Read ↗

The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction.Semantic proximity Read ↗

A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons.Semantic proximity Read ↗

UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.Semantic proximity Read ↗

Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics.Semantic proximity Read ↗

Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.