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Article

The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.

Cell reports - 6 Nov 2014

Chuang Marian, Goncharov Alexandr, Wang Shaohe, Oegema Karen, Jin Yishi, Chisholm Andrew D

Abstract excerpt

Precise regulation of microtubule (MT) dynamics is increasingly recognized as a critical determinant of axon regeneration. In contrast to developing neurons, mature axons exhibit noncentrosomal microtubule nucleation. The factors regulating noncentrosomal MT architecture in axon regeneration remain poorly understood. We report that PTRN-1, the C. elegans member of the Patronin/Nezha/calmodulin- and...

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Identifiers

PMID: 25437544
DOI: 10.1016/j.celrep.2014.09.054
PMCID: PMC4250830

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