Article
Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans.
Development (Cambridge, England) - 1 Mar 2008
Gabel Christopher V, Antoine Faustine, Antonie Faustine, Chuang Chiou-Fen, Samuel Aravinthan D T, Chang Chieh
Abstract excerpt
The molecular and cellular mechanisms that allow adult-stage neurons to regenerate following damage are poorly understood. Recently, axons of motoneurons and mechanosensory neurons in adult C. elegans were found to regrow after being snipped by femtosecond laser ablation. Here, we explore the molecular determinants of adult-stage axon regeneration using the AVM mechanosensory neurons. The first step in AVM axon...
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