Article
Axon regeneration pathways identified by systematic genetic screening in C. elegans.
Neuron - 22 Sept 2011
Chen Lizhen, Wang Zhiping, Ghosh-Roy Anindya, Hubert Thomas, Yan Dong, O'Rourke Sean, Bowerman Bruce, Wu Zilu, Jin Yishi, Chisholm Andrew D
Abstract excerpt
The mechanisms underlying the ability of axons to regrow after injury remain poorly explored at the molecular genetic level. We used a laser injury model in Caenorhabditis elegans mechanosensory neurons to screen 654 conserved genes for regulators of axonal regrowth. We uncover several functional clusters of genes that promote or repress regrowth, including genes classically known to affect axon guidance,...
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