Article
The synaptic receptor Lrp4 promotes peripheral nerve regeneration.
Nature communications - 19 Jun 2018
Gribble Katherine D, Walker Lauren J, Saint-Amant Louis, Kuwada John Y, Granato Michael
Abstract excerpt
Early during PNS regeneration, regenerating axons emerge from the proximal nerve stump, yet whether they extend simultaneously or whether pioneering axons establish a path for follower axons remains unknown. Moreover, the molecular mechanisms underlying robust regeneration are incompletely understood. Using live imaging, we demonstrate that in zebrafish pioneering axons establish a regenerative path for follower...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Homeodomain Proteins
- LDL-Receptor Related Proteins
- Microscopy, Confocal
- Mutation
- Nerve Regeneration
- Neuroglia
- Peripheral Nerve Injuries
- Receptor Protein-Tyrosine Kinases