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Article

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

3 Nov 2021

Abstract excerpt

Abstract Constitutive NF‐κB activation is associated with cellular senescence and stem cell dysfunction and rare variants in NF‐κB family members are enriched in centenarians. We recently identified a novel small molecule (SR12343) that inhibits IKK/NF‐κB activation by disrupting the association between IKKβ and NEMO. Here we investigated the therapeutic effects of SR12343 on senescence and aging in three...

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Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 34734460
DOI: 10.1111/acel.13486

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