Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

29 Aug 2023

Abstract excerpt

Accumulation of senescent cells accelerates aging and age-related diseases, whereas preventing this accumulation extends the lifespan in mice. A characteristic of senescent cells is increased staining with β-galactosidase (β-gal) ex vivo. Here, we describe a progressive accumulation of β-gal staining in the model organism C. elegans during aging. We show that distinct pharmacological and genetic interventions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37644339
DOI: 10.1007/s11357-023-00909-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changesPMID 37644339Read ↗

Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the C. elegans ModelSemantic proximity Read ↗

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in miceSemantic proximity Read ↗

A lysosomal surveillance response to stress extends healthspanSemantic proximity Read ↗

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic LifespanSemantic proximity Read ↗

Identification of HSP90 inhibitors as a novel class of senolyticsSemantic proximity Read ↗

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypassSemantic proximity Read ↗

Inhibition of <i>CERS1</i> in skeletal muscle exacerbates age-related muscle dysfunctionSemantic proximity Read ↗

A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged miceSemantic proximity Read ↗

Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during agingSemantic proximity Read ↗

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.Semantic proximity Read ↗

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and LifespanSemantic proximity Read ↗

A p21-GFP zebrafish model of senescence for rapid testing of senolytics <i>in vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.