Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence

6 Jan 2024

Abstract excerpt

Aging is a gradual process of natural change that occurs after reaching sexual maturity. It is also a known risk factor for many chronic diseases. Recent research has shown that senolytics can extend the lifespans and health spans of model organisms, and they have also been demonstrated effective in treating age-related diseases. In this study, we conducted a high-throughput screening of 156 drugs that targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38184267
DOI: 10.1016/j.exger.2024.112359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitor PF-04691502 works as a senolytic to regulate cellular senescencePMID 38184267Read ↗

Comparative Analysis of drugs that improve the Quality of Life and Life ExpectancySemantic proximity Read ↗

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging InterventionsSemantic proximity Read ↗

Senescence Inducers and Senolytics – Pathways and Drugs Targeting Cellular SenescenceSemantic proximity Read ↗

Targeting cellular senescence with senotherapeutics: senolytics and senomorphicsSemantic proximity Read ↗

Recent Advances in Senolysis for Age-Related DiseasesSemantic proximity Read ↗

Current senolytics: Mode of action, efficacy and limitations, and their future.Semantic proximity Read ↗

Senolytics: A Translational Bridge Between Cellular Senescence and Organismal AgingSemantic proximity Read ↗

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational ChallengesSemantic proximity Read ↗

Therapeutic strategies targeting cellular senescence for cancer and other diseasesSemantic proximity Read ↗

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.Semantic proximity Read ↗

Senotherapeutics in Cancer and HIVSemantic proximity Read ↗

Discovery, development, and future application of senolytics: theories and predictions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.