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Article

NF-κB activation with aging: characterization and therapeutic inhibition.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Zhao Jing, Li Xuesen, McGowan Sara, Niedernhofer Laura J, Robbins Paul D

Abstract excerpt

Aging is a condition characterized by progressive decline in tissue homeostasis due, at least in part, to the accumulation of replicative, oxidative, and genotoxic stress over time. The activity of the transcription factor NF-κB is upregulated in both naturally aged mice and multiple progeroid mouse models of accelerated aging. Suppressing NF-κB activity genetically or pharmacologically has been shown to delay...

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PMID: 25736771
DOI: 10.1007/978-1-4939-2422-6_32

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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