Article
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions.
GeroScience - 1 Jun 2025
Elmansi Ahmed M, Kassem Abraham, Castilla Rafael M, Miller Richard A
Abstract excerpt
Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine anti-aging interventions produce lower levels of pro-inflammatory proteins. Here, we explore the hypothesis that different longevity interventions diminish NF-κB levels, potentially mediating some of the anti-inflammatory benefits of lifespan-extending interventions. We found that the NF-κB...
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